Januvia
February 23rd, 2008The U.S. Food and Drug Administration (FDA) has approved of Januvia (sitagliptin phosphate) oral tablets, made by Merck & Co., the first in a new class of drugs known as DPP-4 inhibitors. Januvia works by blocking the activity of an enzyme called dipeptidyl peptidase IV, or DPP-4, that breaks down the proteins that increase the release of insulin. This gives the proteins more time to work and this, in turn, enhances blood-sugar control.
Januvia lowers blood sugar level, especially after meals and also between meals. It helps to increase the levels of insulin produced by your body after a meal. It decreases the amount of sugar made by the body. It cannot cause hypoglycemia (low blood sugar level) because it does not work when the blood sugar level is low.
The medicine is specifically approved for use in case of type 2 diabetes mellitus that cannot be controlled by either diet or exercise. Don’t use it if you are a type 1 diabetes mellitus patient or if you have diabetic ketoacidosis, that is, increased ketone level in the blood or urine.
Use Januvia exactly as prescribed by your doctor. Januvia is taken orally either with or without food. Your doctor may prescribe lower doses of Januvia if you have kidney problems. Your doctor may also prescribe Januvia along with other medicines that lower blood sugar level. Don’t take an overdose of Januvia. If you have accidentally taken too much of Januvia, call your doctor or the local Poison Control Center immediately.
You might experience side effects such as upper respiratory infection, stuffy or runny nose, sore throat, and headache when you are taking Januvia. Occasionally, Januvia may also cause stomach discomfort and diarrhea.
A lot of study still needs to be done on Januvia. It has not yet been studied in children under the age of 18. Its effects when taken with medicines that cause low blood sugar, such as sulfonylureas or insulin, are not yet known. Give your doctor the entire list of medicines, including the vitamins and supplements that you are taking. The effects of Januvia on the human fetus are still not known. Januvia may pass on to the baby through its mother’s milk. So, pregnant women and nursing mothers need to take their doctor’s advice before taking Januvia.